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Principal Scientist, Peptide Chemistry


This is a Full-time position in Pittsburgh, PA posted March 26, 2021.

nn About the Position nn nn n nn nnThe Principal Scientist, Peptide Chemistry position contributes to research and development to advance discovery and development of peptide therapeutics.

The position operates in close collaboration with experts in machine learning, computational biology, data engineering, and platform software development.nn nn n nn nn Job duties and responsibilities: nn Independently designing and synthesizing drug-like peptide molecules utilizing current medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.

Scientific leadership of peptide modeling.

Design the chemical synthesis (solid phase peptide synthesis and peptide arrays) for peptides, peptide modifications and peptide conjugates.

Work within a team of chemists to synthesize, purify, and analyze peptides.

Assess inquiries for more complex peptides, peptide derivatives and modification with respect to feasibility, resources, and costs.

Development of protocols for upscaling and management of transfer projects or 3rd parties.

Conduct qualitative and quantitative experiments to develop plans and design to test their suitability for large-scale use.

Synthesize polymeric supports for peptide synthesis; synthesize loaded amino acid resins; synthesize peptides using solid phase and solution phase protocols, and purify crude peptides using HPLC and/or flash chromatography.

Determine purity and integrity of peptides using spectroscopic and chromatographic methods.

Write standard operating procedures and reports.

nn n nn nn Education and experience: nn PhD in Peptide / Medicinal or Organic Chemistry or related field.

At least 2-5 years of experience in Peptide Chemistry ideally in academia or within the life science or pharmaceutical industry, or in chemical R&D or manufacturing.

Sound scientific background, ideally in large scale, solid phase, peptide synthesis / peptide arrays nn n nn nn Diversity & Inclusion: Our Foundation for Innovation nn nn n nn nnAt Peptilogics, diversity, inclusion and equality are embedded in our DNA.

Together, regardless of gender, race, ethnicity, national origin, age, sexual orientation or identity, education or disability, the Peptilogics team envisions a workplace where all employees feel valued and respected.

We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our team members.

nn nn n nn nnPeptilogics is committed to serving as a model of diversity and inclusion for the entire biotech and biopharmaceutical industry and to maintaining an inclusive environment with equitable treatment for all.

It fuels our innovation, reinforces our vision, and more closely connects us to the communities we serve.nn nn nn nn Peptilogics: Leaders in Scalable, Rational Design nn nn n nn nnPeptilogics is a clinical-stage biotechnology company that designs and develops novel peptide therapeutics.

The company leverages machine learning, automation, and peptide synthesis to build platforms for science at scale.

With its foundations in drug development and engineering, the company’s platforms vertically integrate proprietary hardware, software, bioinformatics, chemistry, and molecular biology to advance basic research, target validation, and clinical trials.nn